About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.

Position Purpose:

The Senior Director of Learning and Development will be responsible for leading the design, execution, and management of a comprehensive learning strategy aligned with the company’s scientific and business objectives. The ideal candidate will create training infrastructure from scratch, including launch excellence frameworks and technical training for both medical and commercial teams. This position will report to the Vice President of Marketing.

Key Responsibilities:

Build a comprehensive training strategy aligned with business objectives to enhance knowledge and skills on SMA and zorevunersen across U.S. and global markets.
Lead and oversee medical and commercial training initiatives.
Lead development initiatives, i.e., training, coaching, learning initiatives.
Lead creation and standardization of Launch Excellence frameworks from early planning through post-launch sustainment.
Design and train on learning solutions grounded in adult learning theory to maximize knowledge of retention and application.
Oversee development and facilitation of dynamic workshops on disease states, products, market landscapes, and contextual selling skills for diverse audiences.
Train and coach leaders for key conversations that drive team performance, instilling high confidence in the performance of team members, and ensuring employees receive balanced and actionable feedback.
Partner with executive leaders to provide strategic guidance aligning people programs to business outcomes and while ensuring high employee engagement.
Lead, evaluate and monitor training programs to ensure training objectives are being met.
Ensure the appropriate utilization of resources by overseeing the identification and selection of vendors as well as existing relationships and projects relating to training.
Design and implement practices ensuring continuous improvement of a high-performance culture.
Other duties as assigned.

Required Skills & Experience:

Bachelor’s degree in business, science or related field. A master’s degree (MBA) is strongly preferred.
10+ years of experience working in the pharmaceutical or biotech industry with 8+ years of experience in sales/commercial training.
Ability to lead all medical affairs and commercial trainings.
Experience leading development initiatives (i.e., training programs, feedback and evaluation, collaboration, LMS systems, career development, content creation, digital training assignments, performance consulting, learning analytics and facilitation and coaching).
Firm understanding and applicability of adult learning theory framework and experience with each of the adult learning modules (i.e., visual and spatial, auditory, linguistics, andragogical and experiential learning).
Experience using different learning methodologies.
Strong interpersonal skills with demonstrated ability to drive toward consensus.
Exceptional, persuasive, written, and verbal communication skills. Willingness to present the facts and put forth hypothesis in the face of differing opinions.
Excellent presentation skills with the ability to establish logical flow and story. Experience presenting to senior management.
Ability to adjust to changing needs within the organization and flexibility to change priorities as needed.
Ability to self-direct projects and work independently.
Ability to work cross functionally with key internal stakeholders including, but not limited to Sales, Market Access, Marketing and Human Resources.
Demonstrated values-based skills and strong work ethic.
Pharmaceutical launch experience with an emphasis on building infrastructure and processes from scratch.

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is field-based, currently based in Bedford and will later be based in Waltham.

Travel:

This position will require approximately 25%-30% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $256,000 - $301,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

Stoke Therapeutics jobs

Senior Director, Learning & Development